动物造模,无菌性心包炎模型 z-bio 2021-11-17 830

　　[Model mechanism] Atrial fibrillation usually occurs after thoracotomy, and pericarditis is considered to be an important cause of atrial fibrillation.

　　[Modeling method] Please select a mongrel dog (male or female). After anesthesia, the chest cavity was opened, the opened bag was cut, the heart was exposed, and three pairs of stainless steel wire electrodes were sewn on the designated right atrium and sprinkled on the body. A large amount of sterile talcum powder is wrapped in a gauze cloth on the surface of the atrium, and the pericardium and chest wall are sutured to administer penicillin to fight infection. During the postoperative healing process, atrial fibrillation can be induced by periodic stimulation or by rapidly increasing atrial stimulation for 10-30 seconds.

　　[Model Features] Atrial fibrillation is easily induced within 4 days after surgery. After 7 days, the induction rate of atrial fibrillation dropped to 1/5,

　　[Model Evaluation and Application] Models are easy to create, fast, have a high induction rate, and are often used in therapeutic drug research.