非编码RNA z-bio 2021-04-12 278

　　Liu Mofang, a researcher at the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, was invited by the "Wiley Interdisciplinary Review-RNA" magazine to publish an online review article entitled "Small Non-coding RNA and Male Infertility". This article was completed by researcher Liu Mofang, his research group Dr. Gou Lantao and doctoral student Dai Peng, and summarized the small non-coding RNA functional mechanism and small non-coding RNA abnormalities in the process of animal spermatogenesis. Route and male infertility. The latest research progress.

　　Non-coding RNA is a new type of gene expression regulator that can regulate genome expression at the epigenetic, transcriptional and post-transcriptional levels, and participates in the regulation of almost all eukaryotic life processes. Recent studies have shown that several types of small non-coding RNAs, such as micrornA, endogenous small interfering RNA (endo-siRNA) and piRNA, are expressed in animal male germ cells and are required for animal spermatogenesis. This review paper summarizes and discusses the latest advances in the development and differentiation of these small non-coding RNAs and male germ cells, and looks forward to the future development of this research field.

　　Liu Mofang’s research team is dedicated to studying the physiological and pathological functional mechanisms of small non-coding RNAs. Recent studies have discovered a regulatory mechanism for the synergistic degradation of villi and its binding protein MIWI in late spermatogenic mice (DevCell2013), where piRNA in thick mouse lines is extensively degraded in late spermatogenesis ( CellRes2014). At the same time, it has been proved that microRNA plays a very important regulatory role in the development of inflammation.