动物造模,老年动脉恢复生机 z-bio 2022-01-12 421

　　According to the latest research, antioxidants targeting mitochondria (a special cytoskeleton) can reverse some of the side effects of arterial aging and reduce the risk of heart disease. When the research team fed aging mice (equivalent to 70-80-year-old humans) with water containing a type of MitoQ, their arteries worked well, equivalent to 25-35-year-old humans.

　　Rachel Josia Ryan, a doctoral student in the Boulder School of Cross Physiology at the University of Colorado, and the first author of the paper, said: "The key sign of primary aging is the loss of endothelial cell function." Achel added: "MitoQ can Completely rebuild the endothelial cell function of old mice. They look like young mice." A recent study from the University of Colorado found that antioxidants targeting special cytoskeleton mitochondria may reverse the side effects of certain arterial aging and reduce the risk of The risk of heart disease.

　　When the research team fed water containing a certain MitoQ to aging mice (equivalent to 70-80-year-old humans) 4 weeks later, their arteries worked well and could adapt to the age of 25 to 35. Humanity.

　　Researchers believe that MitoQ may affect the endothelial layer. The endothelial layer is a thin layer of cells that are arranged and combined to form blood vessels. The important function of the endothelium is to help arteries penetrate as needed. As we age, the endothelial layer gradually loses its ability to cause expansion, which increases the risk of cardiovascular disease. Rachel Josia Ryan, a doctoral student in the Boulder School of Cross Physiology at the University of Colorado, and the first author of this article, said: "The key sign of primary aging is the loss of endothelial cell function." MitoQ can completely reconstruct old mice The endothelial cells function and make them look like young mice. The research was published in

　　In the Journal of Psychology, the research was funded by the National Agency for Aging, which is one of 27 national medical institutions and centers and one of the leaders in scientifically revealing natural aging. It causes the blood vessels to dilate. Human aging means that expanded nitric oxide is destroyed by various active reactive oxygen systems (such as superoxide). These forms of oxygen are caused by many components in human cells, such as mitochondria and other organelles. , Superoxide reacts directly with the enzyme that produces NO, initially reducing the production of NO, which means less blood vessel penetration

　　Even a young and healthy body produces mitochondrial superoxide, which requires low levels of superoxide to maintain important cellular functions. Supervise the body's own antioxidants (neutralize superoxide). Oxygen can reduce and prevent oxidative damage to cells.

　　"The human body is in this state of balance, but as we age, this balance will be destroyed." According to Gioscia-Ryan, he taught at the University of Colorado led by Professor Douglas Shields. It provides a more active oxidant that surpasses the defense capabilities of antioxidants," Gioscia-Ryan added. Senescent cells produce more superoxide or other active oxidants. This phenomenon is called oxidative stress. Mitochondria are one of them. The main source of superoxide in senescent cells. These increased superoxides can not only attack NO-related substances, but also attack the endothelial reaction and the mitochondria themselves. Damaged mitochondria gradually lose their functions and produce More active oxidants., mitochondria fall into a terrible cycle.

　　Past research has focused on whether long-term intake of additional antioxidants can improve blood vessel function, thereby rebuilding the balance of superoxide levels in patients with cardiovascular diseases. However, most studies show

　　The uniqueness of this new study is that MitoQ is a specific targeted antioxidant that targets mitochondria. Biochemists support MitoQ by adding molecules to Q10. Other molecules can concentrate ubiquinone in mitochondria

　　"The question is why you can't eat so much vitamin C." Gioscia-Ryan explained: "Scientists believe that oral vitamin C and other antioxidants cannot enter vitamin C. A reactive oxidation system is created, and MitoQ can basically be traced back to the mitochondria. ."

　　The results indicate that certain targeted mitochondrial strategies may be an effective way to effectively improve the function of aging arteries. MitoQ treatment can improve endothelial cell function. In addition, it can also increase the function of vascular endothelial cells. There is no NO in the arteries of aged mice, which reduces oxidative stress and improves mitochondrial health.