动物造模,AMD治疗药物 z-bio 2021-04-12 441

　　Age-related macular degeneration (age-related macular degeneration, AMD) is usually a natural result of age-related macular degeneration. As we age, the retinal tissue degenerates and becomes thinner, resulting in weakened macular function. In Western countries, macular degeneration is the main cause of blindness in people over 50. In the United States, macular degeneration causes more blindness than glaucoma, cataracts and diabetic retinopathy combined.

　　The incidence of macular degeneration in China is not low. The incidence between 60 and 69 years old is 6.04% to 11.19%. As China’s population ages, this disease is clearly on the rise. Exudative (wet) macular degeneration accounts for about 20% of AMD and is the main cause of visual impairment in more than 90% of patients. Choroidal neovascularization (CNV), retinal pigment epithelial detachment or discoid fibrosis are the main pathological features. Among them, CNV is very important in the development of AMD. The structure of the zebrafish retina is similar to that of humans and most mammals.

　　The larvae of transgenic fluorescent zebrafish were selected, and the FDA-approved drug Avastin was used as a positive drug to observe the area of retinal blood vessels and determine whether the test sample can inhibit angiogenesis. Model of ocular angiogenesis. Then, choose the right medicine quickly, intuitively and accurately.