动物造模,颅骨缺损模型 z-bio 2022-01-14 678

　　Objective: To establish a skull defect model and compare the anesthesia effects of the three anesthesia methods in the mini-pig repair experiment to find the best anesthesia plan that is simple, safe and effective.

　　Method: 30 Guizhou mini-pigs (half male and half) were randomly divided into 3 groups, each with 10 pigs. Group A was injected intramuscularly with a mixture of midazolam and ketamine. Group B was injected intramuscularly. Mianning II injection group C was anesthetized by intramuscular injection of midazolam (a combination of ketamine and Lu Mianning II). Compare the effective time of anesthesia, the maintenance time of the first anesthesia, the maintenance time of the first additional drug anesthesia, the maintenance time of the second additional drug anesthesia, recovery time, the number of additional anesthetics during the operation, the cumulative use of anesthetics and Side effects in animals after surgery. mortality rate.

　　Result: The effective time of group B is longer than that of groups A and C (P\u003c0.05). The length of the first anesthesia maintenance time, the first additional medication anesthesia maintenance time and the second additional medication anesthesia maintenance time. Group C was significantly better than group B (P\u003c0.05); A, C group recovery time was significantly shorter than group B (P\u003c0.05); and increased the number of anesthetics. , The total dose of group C, the incidence of adverse reactions and mortality after operation were significantly lower than those of group A and group B (P\u003c0.05).

　　Conclusion: The combined anesthesia of midazolam + ketamine and Lumione II is easy to operate, the depth of anesthesia is controllable, and the safety is high. It is very suitable for the operation of piglets with long operation time.