动物造模,猪慢性心肌缺血模型 z-bio 2021-12-28 358

　　Aiming at the shortcomings of the previous pig chronic myocardial ischemia model, this study firstly used the mechanism of hyperlipidemia to cause AS, causing coronary artery occlusion or stenosis. The high-fat diet method is used to cause chronic myocardial ischemia in pigs. Supplementary injection can enhance the sensitivity of myocardial ischemia, simulate the induction of sudden coronary heart disease in clinical, and establish a miniature pig chronic myocardial ischemia model. The research model avoids surgical damage, is similar to clinical development, is stable, reproducible, and has few influencing factors, so it can prevent and treat coronary heart disease and the pharmacodynamics of new drugs, and is more suitable for evaluation. At the same time, non-invasive telemetry technology is used to detect and evaluate the symptoms of myocardial ischemia model, and to perform long-term continuous dynamic electrocardiogram detection and heart rate variability analysis in the awake state. This can reflect development and development. Analyze the pathological changes of some model animals, and combine myocardial enzymes, blood lipids, free radicals, myocardial energy metabolism, blood coagulation and electrolyte indicators, and other blood biochemical indicators to perform auxiliary evaluation studies to evaluate the technical specifications of myocardial ischemia model of chronic disease in miniature pigs.

　　Considering that certain household miniature pigs may have particularities in the application of cardiovascular diseases, this study deliberately selected Wuzhishan miniature pigs, Bama miniature pigs, Tibet miniature pigs and hyperlipidemia, and discussed the development of diseases and hypertension. These three types of mini pigs. Various characteristics of AS risk factors, such as blood pressure and hyperlipidemia. Non-invasive telemetry technology combined with blood biochemical indicators is used to assess the transportation stress response of these three types of miniature pigs, and define the adaptation and recovery time of miniature pigs after transportation stress.