动物造模,右心衰竭动物模型 z-bio 2021-04-14 615

　　Right ventricular dysfunction (RVF) means that the systolic and/or diastolic dysfunction of the right ventricle is not sufficient to produce the required cardiac output, or the normal filling pressure cannot be formed due to various reasons. It is mainly seen in pulmonary arterial hypertension (PAH), right ventricular myocardial infarction and left ventricular insufficiency (left ventricular insufficiency, LVF). At present, the disability and mortality rate of RVF is higher than that of LVF, especially the 5-year mortality rate of RVF caused by PAHs is as high as 30% to 50%. However, the current research on RVF lags far behind LVF. The compensation mechanism of the right ventricle in PAH and other diseases and the cellular and molecular mechanisms of right ventricular decompensation are still unknown. Therefore, it is necessary to conduct a detailed investigation of the RVF.

　　The establishment of an effective animal model of RVF plays an important role in the detailed study of the etiology, pathophysiology, prevention and treatment of RVF. However, many RVF animal experiments have different modeling methods and different selection and processing conditions, so no animal model can be identified. This article summarizes the methods of establishing RVF animal models reported in the literature, makes a comparative evaluation, and provides reference materials for future RVF animal experimental studies.