动物造模,常黑胆质证大鼠模型 z-bio 2022-01-17 585

　　Purpose: Combining the observation of external characteristics and the study of urinary metabolomics, to evaluate and discuss the biological markers of the Uyghur medical abnormal Savda biliary syndrome rat model?

　　Method: Uyghur medical abnormal use Savda bile management theory to establish a rat animal model, observe and score various external indicators, such as hair, tongue, sleep, feces, mood, weight gain rate, 1H? Use nuclear magnetic resonance (1H? Nuclear magnetic resonance, 1H? NMR) to detect and analyze urine? Results: Compared with the control group, the rats in the abnormal Savella syndrome model group had external effects such as dry and hard stools, decreased urine output and darker color, dry fur and dark purple tongue coating, and their characteristics had obvious changes. The content of 23 metabolites in urine metabolites was significantly reduced, including propionic acid, lactic acid, alanine, pyruvate, acetic acid, acetamide, glycoprotein, acetone, formic acid, creatine, ornithine, and glycine And creatine. Creatinine? Creatinine? Beta? Galactose? Urate? Tyrosine? Phenylalanine? Uric acid? Amino high purity acid? Does the content of four metabolites of formic acid and lysine, urea, citric acid, allantoin and α-ketoglutarate increase significantly?

　　Conclusion: The rats in the model group not only showed appearance during the development of abnormal savages, but also had obvious changes in various internal metabolic pathways. The urine metabolites of abnormal savages were also abnormal. The symptoms may be related to biological mechanisms.