颅骨缺损动物模型,动物造模 z-bio 2021-10-19 922

　　Objective To explore an ideal method for constructing an ideal rat skull defect model and to improve the success rate of animal models of bone defect.

　　Methods Forty adult male SD rats were selected and randomly divided into control group and experimental group. The control group used the traditional skull defect model surgery method, using only a hollow ring drill bit perpendicular to the surface of the skull to drill the full-thickness skull defect; experiment The group applied an improved surgical method, using both hollow and solid drills, and changed the direction of force of the drill at different stages of the skull drilling process. Compare the operative drilling time of the two models, as well as whether there are complications such as periosteum, dura mater, brain tissue damage and hemorrhage during the operation, and observe whether the alumina bioceramic material implanted in the two models is displaced 8 weeks after the operation. , Loosening and osseointegration, and compare the success rates of model making between the two groups.

　　Results Compared with the control group, the experimental group had significantly shorter operation drilling time (P<0.01), intraoperative complications such as periosteum, dura mater, brain tissue damage, and bleeding were significantly reduced (P<0.05), and postoperative alumina biologics There was no displacement or loosening of the ceramic material (P<005), the material was well integrated with the skull, and the success rate of model building was significantly improved (P<0.05).

　　Conclusion The improved method for constructing a rat skull defect model has the advantages of short surgical drilling time and fewer complications, which can greatly increase the success rate of model building, and can effectively evaluate the bone repair performance of orthopedic implant materials in vivo.