动物造模,遗传性高血压小鼠模型 z-bio 2021-04-21 1061

　　Professor Minsheng Zhu from the Institute of Model Animals of Nanjing University, Professor James TStull from the Southwest Medical Center, and Professor Yang Xiao from the Academy of Military Sciences found that the vascular smooth muscles of MYPT1 tissue-specific knockout mice are highly sensitive to GPCRs.

　　Under non-physiological stimulation, the blood pressure of mice reached 140 mmHg at 3 weeks of age, and the range of change was stable. Mice lacking MYPT1 are expected to become the most ideal commercial hypertension model for basic research and screening of various drugs. This model has three advantages. For the first time, a phenotypic stable mouse model of hereditary hypertension without intervention has been established. The functions of vital organs such as the heart and kidneys are normal, and changes in gastrointestinal function and survival are not important. This is pure myogenic hypertension.

　　Almost all types of antihypertensive drugs are sensitive, including ROCK inhibitors, PKC inhibitors, nitric oxide and acetylcholine. In addition, it is worth noting that the male mice in this model are difficult to mate and can be used in male erectile dysfunction (ED) disease models.

　　The main authors of this article are graduate students Qiao Yanning and Dr. He Weiqi from the Institute of Animal Modeling. After more than six years of hard work, they have completed a series of phenotypic and mechanism studies of animal genome changes. position. The corresponding author of this article is Professor Minsheng Zhu from the Institute of Model Animals.