动物造模,裸鼠人来源性子宫腺肌病造模 z-bio 2022-01-13 317

　　Purpose: Through a variety of modeling techniques, select ideal modeling techniques, study the etiology and related treatment of adenomyosis, and provide an ideal animal model for the establishment of nude mouse human adenomyosis model.

　　Method: 80 female nude mice were randomly divided into abdominal transplantation group, subcutaneous transplantation group, intraperitoneal injection group and subcutaneous injection group, with 20 mice in each group. Each model group uses a different modeling method to build a human model of nude mouse adenomyosis. The volume and tissue morphology of the graft were observed 4 weeks after operation.

　　Results: The modelling success rate of the abdominal implant group was 95%, the modelling success rate of the subcutaneous implant group was 45%, and the modelling success rate of intraperitoneal and subcutaneous injection was 0%.

　　Conclusion: The nude mouse model of adenomyosis established by peritoneal transplantation is an ideal human-derived adenomyosis animal model, with a high modeling rate and good stability.