动物造模,大鼠子宫角瘘管模型 z-bio 2022-01-06 429

　　Objective: To explore the feasibility of placing a fistula catheter in the uterine horn of rats.

　　Method: After the rats are anesthetized, a fistula catheter is placed near the uterine horn of the terminal uterus, and the histopathology and pregnancy function are studied.

　　Results: Compared with the control group (537.90±77.29) μm and the contralateral uterine horn (503.56±76.34) μm in the rat endometrial thickness fistula model group Not significant (P>0.05); the number of rat embryo implanted in the fistula model group (9.67±1.95) was significantly less than that in the control group (12.15±2.06) (P<0.05); the="" fistula="" side="" uterine="" horn="" in="" model="" group="" there="" was="" no="" significant="" difference="" between="" and="" contralateral="" p="">0.05).

　　Conclusion: The uterine horn fistula catheter model has little effect on rat uterine tissue structure, and can meet the test requirements of long-term injection of pathogenic microorganisms or chemical drugs into the uterine cavity.