动物造模,慢性胃肠黏膜损伤树鼩模型 z-bio 2021-04-27 281

　　Objective: To explore the feasibility of establishing an animal model of chronic gastrointestinal mucosal injury in tree shrews.

　　Method: Twelve adult male tree shrews were randomly divided into three groups. Experiments 1 and 2 are 2 mg/(kg?D) and 1 mg/(kg?D)1? methyl? Four? Phenyl? Can be divided into 1 and 2, 3, 6? The control group was given the same amount of tetrahydropyridine (MPTP). The control group was given the same amount of normal saline, and the experimental tsupai was injected intraperitoneally for 56 consecutive days. The weight change was observed, and the dopamine content was measured by the cerebrospinal fluid. Histopathological changes.

　　Results: The cerebrospinal fluid weight and dopamine content of the model group were significantly reduced. The gastric antrum, gastric body and duodenum all had different degrees of pathological changes, but there was no significant difference between 2 mg/kg, and there was no significant difference between them. difference. There was no significant change in the 1 mg/kg group and control group.

　　Conclusion: Long-term low-dose intraperitoneal injection of MPTP is a feasible method to simulate the tree sh with chronic gastrointestinal mucosal damage.