实验鼠皮肤细胞 z-bio 2021-04-28 270

　　According to the official website of the Singapore Science and Technology Research Agency, the research teams of the Institute of Genomics and the Institute of Molecular Cell Biology under the Agency have successfully programmed experimental mouse skin cells to directly obtain blood cells and immune cells, which is a step towards using human skin cells to regenerate human blood cells. The ultimate goal has taken an important first step.

　　One of the main challenges of regenerative medicine is to create new blood and immune cells for patients on demand. Previously, researchers also reported that the skin cells of experimental mice were used to regenerate hemorrhage cells, but the resulting blood cells could only survive for two weeks after being reinjected into experimental mice. The blood cells obtained in this latest study published in the journal Nature Communications can remain active in experimental mice for several months and will provide immune cells for patients with abnormal immune function and other patients who need blood transfusion. Or fresh blood provides strong protection.

　　In this study, the Singapore team used a "cocktail" method to mix 4 factors that can transform the skin cells of experimental mice into different types of blood cells. They extracted these four factors that maintain normal activity from the blood of experimental mice, introduced them into the skin cells, artificially reprogrammed the skin cells, and artificially "rewritten" the skin cells to accept the functions of blood cells, so that these skin cells It directly possesses the characteristics of blood cells. The first author of the paper, Cheng Hui (transliteration), said: "With the introduction of these four factors, there is almost no difference between skin cells and blood cells."

　　Kyle Lu, a former member of the experimental group and now working at the Institute of Hepatocyte Biology and Regenerative Medicine at Stanford University, added that the new research can produce a large amount of fresh blood or immune cells, which not only has important practical significance for regenerative medicine, but also It has basic biological significance, because research shows that skin and blood, two completely different cells, can be converted to each other through direct programming.

　　Researchers also said that new research breakthroughs may completely change regenerative medicine. Once the same results are obtained in human cell research, a large number of patients will benefit from it.