动物造模 z-bio 2021-04-28 303

　　Objective: Diagnose and treat Beagle dogs infected with Demodex mites, and observe its histopathology.

　　Method: direct smear for microscopic examination, routine paraffin section, HE staining for histopathological observation.

　　Results: (1) Clinical observation: erythema, alopecia, skin thickening and wrinkles appeared on the limbs, eyes, lower abdomen and other parts of the affected dog; (2) Regular blood examination: basically normal; (3) Microscopic observation: Many small Demodex mites and eggs were found; (4) Histopathological observation: Many demodex mites and eggs were found in the hair follicles. In addition, the sebaceous glands and sweat glands have normal structures and are free of mites infestation. A large number of eosinophils and neutrophils infiltrate around the hair follicles, leading to the formation of multiple granulomatous disease. The granuloma is oval in shape. (5) Treatment plan: combined drug treatment, strengthening environmental control, and obvious therapeutic effect.

　　Conclusion: Demodex granuloma can be classified as immune granuloma. After infection, small insects may not destroy the sebaceous glands. Whether the sebaceous glands are infected by insects may be related to the type of insects and the course of the infection.