动物造模,Ⅱ糖尿病,骨质疏松 z-bio 2021-12-15 667

　　Objective: To explore the palliative effect of flunaetine on osteoporosis in rats with type 2 diabetes and diabetic bone disease.

　　Method: Use streptozotocin (STZ) + high-fat diet to establish a type 2 diabetes rat model, and oral high, medium and low mass concentrations (100 mg/kg, 50 mg) to the diabetes model rats. After 2 weeks at 20 mg/kg and 20 mg/kg of formononetin), each group was tested for femoral mineral density, serum testosterone (T) and estradiol (E2) levels, and rat femur osteocalcin (OC). Kidney CYP24A1 mRNA expression level.

　　Result: Compared with the normal group, the type 2 diabetes group has lower bone mineral density, serum T and E levels, femoral OC and renal CYP24A1 mRNA expression, but Formononetin can reverse the above phenomenon and is the best. The effect of high concentration group is good.

　　Conclusion: Formmonidine can effectively reduce osteoporosis in rats with type 2 diabetes and diabetic bone disease.