动物造模,大鼠高血压,血管内皮功能模型 z-bio 2021-04-29 398

　　Objective: To investigate the effect of Jiawei Wuzhuyu Decoction on blood pressure and vascular endothelial function in hypertensive rats induced by high-sugar and high-fat diet and alcohol.

　　Method: Select 100 SPF male SD rats, 20 normal control groups, and prepare 80 hypertension models with high-sugar and high-fat diet and gradient drinking. The 80 successfully modeled rats were randomly divided into four groups, hypertension model group, Jiawei Wuwuyu Decoction low-dose treatment group, medium-dose treatment group and high-dose treatment group, each group placed 20 rats I do The treatment group was given different concentrations of Jiawei Wuzhuyu Decoction every day, and the rats in the normal control group and the hypertension model group were added with distilled water. Before the experiment, after successful modeling (before administration) and after treatment, the systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MBP) and heart rate (HR) were measured. Enzyme immunoassay (ENOS) was used to determine cell adhesion molecule-1 (ICAM-1), endothelin-1 (ET-1), nitric oxide (NO) and endothelial nitric oxide synthase in serum before and after treatment. . ..) Level. Results Compared with the post-modeling (before administration), the SBP, DBP and MBP of each treatment group were significantly increased compared with the normal control group (P0.05). Compared with the normal control group, the levels of ICAM-1 and ET-1 in each treatment group increased significantly, and the levels of NO and eNOS decreased significantly (P\u003c0.05). Compared with hypertension model group and medium type. The levels of ICAM-1 and ET-1 in the high-dose treatment group of Jiawei Wuzhuyu Decoction were significantly increased, but the levels of NO and eNOS were significantly decreased (P\u003c0.05).

　　Conclusion: High-dose Jiawei Wuzhuyu Decoction has obvious antihypertensive effect on high-sugar, high-fat and hypertensive rats induced by drunkenness.