动物造模,阿尔茨海默病 z-bio 2021-05-07 570

　　Objective: To analyze the brain imaging characteristics of tree shrews in Alzheimer's disease (AD) models.

　　Method: Aβ1-40 was injected into the upper cerebral ventricle of the stereotaxic device to establish an AD animal model. After the visuospatial behavior test confirmed the success of the model, MRI was used for coronary artery T2-weighted image (T2WI) and diffusion tensor image (DTI) analysis.

　　Results: The reference memory errors (3 weeks, 4 weeks) and working memory errors (2 weeks, 3 weeks, 4 weeks) of the model group were significantly higher than those of the control group (P\u003c0.05). ). The time it took for the model group to complete the task (2 weeks, 3 weeks) was significantly longer than that of the control group (P\u003c0.05). Starting from 3 weeks, the tree rew in the model group decreased in the hippocampus on one or both sides, and increased in the corresponding lateral or bilateral ventricles. After 12 weeks, the width of the bilateral temporal lobes of the tree sh in the model group was significantly larger than that of the control and treatment groups (P\u003c0.01). The diffusion tensor image scan showed that the apparent diffusion coefficient (ACD) on both sides of the hippocampus sh tree in the model group was higher than that in the control group (P\u003c0.01). The body fiber bundles in the model group are severely missing.

　　Conclusion: Injecting Aβ1-40 into the lateral ventricle may cause learning and memory loss of the tree sh. MRI can show the characteristic changes in AD Treeshrew's brain. Temporal lobe width, hippocampal ADC value and call body fiber damage have reference value for the diagnosis of dementia.