动物造模,功能性消化不良脾虚证 z-bio 2021-05-08 575

　　Objective: To explore the establishment and comparison of animal models of functional dyspepsia and spleen deficiency syndrome.

　　Method: Use iodoacetyl group and joint small platform standing or joint swimming to establish a functional dyspepsia spleen deficiency rat model. I modeled the excretion of lactic acid, gastrin and D-xylose in urine by observing the general condition of the animals, changes in body weight and food intake, serum motilin, cholecystokinin content, and the amount of lactic acid, gastrin and D-xylose excretion in urine. I evaluated Effect.

　　Result: The weight of rats in the iodoacetamide single factor group slowed down and their food intake decreased. Rats in the complex factor group had symptoms of spleen deficiency, such as weight loss, dry hair, diarrhea and high urine excretion rate. The contents of D-xylose and serum gastrin and gastrin were significantly reduced, but the contents of serum cholecystokinin and lactic acid were significantly increased.

　　Conclusion: The three modeling methods all cause the symptoms of functional dyspepsia, but the symptoms of spleen deficiency are more obvious in the compound factor treatment group, and the iodoacetamide compound small platform standing method is the most prominent and effective.