动物造模,蛛网膜下腔出血模型 z-bio 2021-05-08 745

　　Objective: Through the combination of pictures and text, elaborate the method and process of establishing subarachnoid hemorrhage rat model, and improve and innovate the model to better simulate the subarachnoid hemorrhage caused by the rupture of clinical aneurysm .

　　Method: select SD male rats, and use the method of penetrating the internal carotid artery into the internal carotid artery to establish a subarachnoid hemorrhage model of the SD male rat. Rats were dissected by breathing, pupils, urine, excrement and indwellings. Fiber core. Use methods such as head and neck to validate the model. Through observing the mortality and clinical symptoms, the controllability and repeatability of the model were discussed.

　　Result: Vascular puncture can cause subarachnoid hemorrhage, and the position of the fiber core can accurately puncture the desired blood vessel.

　　Conclusion: This method is stable, easy to understand, well-designed, flexible and reproducible. The model can be successfully modeled in a short time after understanding, and can improve the subarachnoid hemorrhage caused by the successful model. The sudden rupture and bleeding of clinical aneurysm is very suitable for the study of early brain injury and vasospasm of subarachnoid hemorrhage.