动物造模,2型糖尿病 z-bio 2021-12-01 656

　　Objective: To establish and analyze the characteristics of plasma metabolomics changes in an abnormal type 2 diabetes (T2DM) rat model of black gallbladder syndrome in Uyghur medicine.

　　Method: Establish a rat model of T2DM Uyghur drugs with abnormal barbaric syndrome, collect plasma samples, test proton NMR spectra, and perform multivariate analysis on the data.

　　Results: The plasma glucose and lactic acid content of rats in the simple abnormal brutal syndrome group decreased, but the VLDL, LDL and carnitine content increased significantly (P\u003c0.05); T2DM Uyghur medical abnormalities combined with Saba syndrome group disease and symptom syndrome amino acids (Alanine, isoleucine, valine, leucine, tyrosine, glutamic acid, phenylalanine, methylhistidine, glycine) and lactate pyruvate, sugar in rat plasma Protein, citric acid, creatine,-hydroxybutyric acid content acid, acetoacetic acid, lactic acid, creatinine, carnitine, silanol, VLDL, LDL all decreased, but glucose and taurine content increased significantly (P\u003c0.05 ).

　　Conclusion: In T2DM Uyghur medical abnormal scombroid syndrome model rats with diseases and syndromes, protein metabolism, phenylalanine and tyrosine metabolism pathways, glycolysis pathways and lipid metabolism pathways have undergone significant changes ; Plasma metabolism, Omics changes reflect pathological changes to a certain extent. This situation occurs in the Uyghur medical rat model of T2DM with abnormal Saba syndrome (a combination of disease and syndrome).