动物造模,慢性心肌缺血 z-bio 2021-05-11 279

　　Objective: To explore the feasibility of a series of methods to treat a piglet model of chronic myocardial ischemia. In this model, the humanoid stenosis ring is surgically inserted into the left anterior descending artery?

　　Method: A model of chronic myocardial ischemia in piglets with the left anterior descending branch of the Bama caterpillar was established. The narrow ring of humanoid animals was placed in the model, and it was placed in the treatment group ("Neiguan" puncture") and the control group ( "Zu Sanli"). Randomly divided into puncture). Point), and buried needles at the "Neiguan" and "Zusanli" points respectively, combined with electroacupuncture, will materials be collected after six weeks?

　　Result: Postoperative gross pathology showed that there are ischemic areas in both groups. The "Zusanli" point is larger than the "Neiguan point", indicating the upper structure of the cardiomyocytes. Are there mitochondrial vacuolation in both groups? Fibrosis?

　　Conclusion: Puncture at the "neiguan" of the pericardial meridian can protect the myocardium by reducing myocardial ischemia. Can it inhibit the existing myocardial ischemic injury? Does it indicate that a humanoid contraction ring can be placed in the anterior descending branch of the left coronary artery and then treated with acupuncture to establish a large experimental animal model of chronic myocardial ischemia in pigs?