动物造模,慢性胃肠黏膜损伤 z-bio 2021-05-11 361

　　Objective: To explore the feasibility of establishing an animal model of chronic gastrointestinal mucosal injury in tree shrews.

　　Method: Divide 12 adult trees into 3 groups randomly. Experiments 1 and 2 are 2 mg/(kg?D) and 1 mg/(kg?D)1? methyl? Four? Phenyl? Can be divided into 1 and 2, 3, 6? The control group was given tetrahydropyridine (MPTP) dose and the same amount of normal saline, and experimental psoralen was injected intraperitoneally for 56 days, the weight change of psoralen was observed, and the dopamine content of the cerebrospinal cord was observed. Detect body fluids and observe the morphology of the gastrointestinal tract under a microscope to show histopathological changes.

　　Results: The cerebrospinal fluid weight and dopamine content in the model group were significantly reduced. The gastric antrum, gastric body and duodenum all had different degrees of pathological changes, but there was no significant difference between 2 mg/kg. There was no significant change in the 1 mg/kg group and the control group.

　　Conclusion: Long-term low-dose intraperitoneal injection of MPTP is a feasible method to simulate the tree sh model of chronic gastrointestinal mucosal injury.