动物造模,肾毒血清肾炎 z-bio 2021-05-11 1220

　　Is the nephrotoxic serum nephritis (NTSN) model created by immunizing animals with a single intravenous injection of nephrotoxic serum nephritis, and is it mainly used to study immune complex-mediated crescent nephritis? The TSN modeling process involves the selection of susceptible laboratory animals (WKY rats). Most SD rats)? Extract the glomerular basement membrane? Prepare nephrotoxic serum? The method of establishing accelerated or non-accelerated models is troublesome, but is the pathological change typical? The immune system of the TSN model is relatively complicated. Does humoral immunity form an in situ circulating immune complex that mediates type III hypersensitivity during the foreign body reaction and autoreaction phase? Does cell-mediated immunity also participate in the formation of kidney crescents by activating T lymphocytes to produce a series of inflammatory factors? Does this article focus on comments on how to model the NTSN model and its immune mechanism?