动物造模,光照血栓中风模型 z-bio 2022-01-31 264

　　Stroke has a high fatality rate, disability rate and recurrence rate. It is an insurmountable disease for human beings. It is mainly divided into hemorrhagic stroke and ischemic stroke. The latter accounts for 80% of all strokes. Scientists are studying effective drugs to prevent and treat stroke. A convenient and practical model is a very important support and guarantee in the study of pathological mechanisms and drug screening. Among many ischemic stroke models, is the mild thrombosis model easy to operate and less traumatic? Do you need a skull incision? Is the fatality rate low? And are other unique benefits increasingly recognized? This model can control the position of thrombus formation by adjusting the position of the laser that irradiates the brain. Model dye dose and laser irradiation intensity and duration, ischemic stroke, cell and molecular mechanism research, and control of the size of ischemic focus suitable for neurodegeneration, neuroprotection and nerve regeneration during development, overview of anti-stroke drugs ? Does this article explain the principles, advantages and disadvantages of the photothrombotic stroke model and its application in drug development?