动物造模,犬心房颤动模 z-bio 2021-05-12 879

　　Purpose: To track the onset of atrial fibrillation and establish a model of atrial fibrillation by innovatively using microelectrode leads in the traditional conventional high-frequency atrial pacing modeling technology, advanced catheter manipulation system and implantable ECG monitor.

　　Method: Select 12 adult beagle dogs and randomly divide them into a blank control group (6 dogs) and atrial fibrillation model group (6 dogs in the AF group). The Select Secure system implant with fine bipolar solid electrode leads used by AF Group is only 4.1Fr in diameter. 3830 actively fixes the electrode, connects a special atrial fibrillation model pacemaker to establish atrial high-frequency pacing system, and uses rapid atrial pacing in AOO pacing mode to establish postoperative atrial fibrillation, and uses the embedded ECG monitor Reveal LINQ Tracker for tracking. Atrial fibrillation occurs in real time? A cardiac color ultrasound imager with a probe emission frequency of 2.5 MHZ was used to perform echocardiography on the experimental dog, and the left side was measured through the four chambers at the apex of the heart. The right atrium at the end of systole? Observing the morphology of left atrium tissue under optical and electron microscope?

　　Result: Among the 12 experimental dogs, 2 of the AF group died during the modeling process, and the remaining 10 died. Has the experimental dog completed the experiment? The time to successfully establish atrial fibrillation model was (10.63±2.13) weeks. Once the atrial fibrillation model is successfully established, whether to set the pacemaker atrial stimulation frequency of the high-frequency atrial fibrillation model in AOO mode (588.75±11.26) times/min? The embedded ECG monitor can accurately and effectively track and record the atrial fibrillation load of the AF group. After creating a successful atrial fibrillation model, the area of the left atrium increased significantly. Before modeling ((8.20±0.83) cm2 and (3.80±0.08) cm2, P\u003c0.05]; the area of the right atrium is larger than before modeling [(4.52±0.44) cm2 and (2.75±) 0.96) cm2, P \u003c0.05]; The area of the left atrium in the AF group was larger than that in the control group [[3.72±0.15) cm2, (8.20±0.83) cm2, compared with P\u003c0.05]]; the area of the right atrium increased compared to the control group [(2.78 ±0.18) cm2 ratio (4.52±0.44) cm2, P\u003c0.05]? Atrial flutter model dogs and blank control group observe the changes of left atrial tissue slice morphology. Does the dog indicate that the atrial structure of the atrial flutter test dog has been modified?

　　Conclusion: Can a stable atrial flutter model be established when high-frequency atrial pacing has successfully produced it? Implanting the 3830 bipolar solid atrial pacemaker using the electrodes of the SelectSecure system, can this method accurately implant the electrodes and improve the success rate of electrode implantation in experimental dogs? The implanted ECG monitor RevealLINQ can be used for real-time dynamic monitoring of atrial flutter load. Can it improve the efficiency of experimental monitoring? Is it efficient? Is it accurate?