Nickel is a metal element that is widely exposed to humans in life and production, and is an essential trace element for the human body, but if it accumulates too much, it will cause harm to the human body. At present, the damage mechanism of nickel poisoning to the human body is still unclear, and further research and discussion are needed. The nickel injury poisoning model is the basis for studying the mechanism and treatment methods of nickel injury. Different nickel damage poisoning models have different preparation properties. Different experimental animal models must be selected for different experimental purposes.