血友病鼠关节病模型,动物造模 z-bio 2021-10-09 281

　　Hemophilic arthritis is a debilitating disease caused by spontaneous intra-articular hemorrhage and recurrent intra-articular hematoma. Its main clinical manifestations are chronic pain, joint damage and poor quality of life. The biological mechanism is not yet fully understood. The current transformed animal models of hemophilia have important value in determining the pathophysiology of the disease and its complications.

　　Therefore, it is necessary to establish a hemophilic arthritis model to further study the pathophysiological mechanism of hemophilic arthritis and potential interventional treatment methods. Because hemophilia mice are easy to transport and assemble, they have become the animal model of choice for researchers. The hemophilia arthritis model will also become the basis of future clinical research. To this end, we will discuss the construction and research of mouse arthritis models of hemophilia.