抽动障碍,动物造模 z-bio 2021-12-16 328

　　Tic disorder is a common neurodevelopmental disorder in childhood, mainly manifested as involuntary repetitive sudden movements and vocalizations. It may be accompanied by attention deficit hyperactivity disorder, learning disabilities, obsessive-compulsive disorder and behavioral disorders. It has a serious impact on children's learning, social adaptability and mental health development.

　　However, its etiology, pathogenesis and pharmacological mechanism are not yet fully understood. These basic studies need to be further studied and verified through animal models. At present, there are many methods to establish tic disorder models, mainly based on the possible causes of the disease, such as neurotransmitter abnormalities, immune disorders, and genetic factors. However, the establishment of a complete animal model cannot meet the requirements of tic disorders.

　　This article summarizes the commonly used animal models of tic disorder for reference in experimental research.