克罗恩病,动物造模 z-bio 2021-10-19 950

　　Crohn's disease is a chronic inflammatory bowel disease, and its etiology has always been a hot and difficult point in medical research. Choose an animal model suitable for the study of the disease, explore potential therapeutic targets, and develop new therapies.

　　With the development of molecular biotechnology, animal models that can be used to study Crohn’s disease have ranged from chemically induced animal models to later spontaneous animal models, and cell transplantation animal models are now widely used and are becoming more and more. diversification. Second-hand researchers are increasingly making appropriate choices, such as genetically modified animal models.

　　This article mainly summarizes the pathogenesis, advantages and disadvantages of these animal models, and provides reference materials for basic research.