NK细胞免疫功能缺陷,动物造模 z-bio 2022-07-04 1084

　　Beige mice are mutant mice with immunodeficiency in NK cells, and bg is a recessive mutant gene on chromosome 13. The outer skin of homozygous (bg/bg) is intact, but the hair is lighter, the auricle and tail tip are less pigmented, and the eye color at birth is very light. The phenotypic characteristics are similar to those of human Zi-Hych syndrome. The lack of endogenous NK cell function in beige mice is caused by the destruction of the recognition process after cell lysis. The homozygous bg gene also impairs the function of cytotoxic T cells, reduces the chemotaxis and bactericidal activity of granulocytes, delays the development of anti-tumor killing effects regulated by macrophages, and leads to lysosome development, and affects and leads to lysozyme Body membrane. The lysosomal function of the relevant cells is defective.