母婴分离模型,动物造模 z-bio 2021-05-18 386

　　Objective Maternal Separation (MS) has always been a classic animal model for studying the neurobiological mechanism of the adverse effects of early stress on individual physiology and psychology (as an important early social deprivation). This article reviews the biological mechanisms related to the general behavioral paradigm of multiple sclerosis models in rats and mice, and reveals the various effects of the duration and frequency of mother-infant isolation on experimental results.

　　The latest methods through Wanfang, CNKI, Pubmed and other platforms. The MS model is used to explore relevant literature on the long-term cognitive and psychological effects of adolescent stress on rats and mice, and to evaluate behavioral methods and results. Article and its underlying mechanism. Results The establishment of a rodent MS model provides a new way for people to explore long-term psychosomatic diseases related to childhood adverse events, and has shown wide applicability. Conclusion At present, various studies have made some progress on this basis, and various studies have been conducted on the cognition, psychological changes and pathogenesis of animal models. However, the cognitive and behavioral changes caused by different separation frequencies and durations are still uncertain, so further research is needed to further study their effects on the gene expression of offspring and parents.