动物造模 z-bio 2021-10-07 755

　　In the scientific community, rodents are the most commonly used experimental subjects. In the United States, as many as 95% of animal research is conducted in rodents. The European Union also found that 79% of animal modeling experiments in this study were conducted on rodents.

　　Interestingly, we don’t know how many mice were used in the research and experiments. The United States Department of Agriculture tracked many species used in the experiment, including birds, dogs, cats, rabbits, and even guinea pigs, but they completely counted the number of rats and mice used in the study, and there is no one in the United States. (Laboratory mice and mice are also not protected by the Animal Welfare Law.) Since 1965, the number of academic literature on mice and mice has tripled compared with other disciplines (dogs, cats, guinea pigs, and rabbits). Variety.

　　Why does the laboratory use so many mice? There are many reasons related to the actual operation: they are relatively small, easy to supply, and relatively cheap. If you need to use a large number of subjects in an experiment, and need to involve multiple generations of subjects, it is difficult to have other subjects that are better than rats and mice. In addition, since it is a mammal, it belongs to the same category as humans and is almost the same as humans. In addition, both rats and mice can mate between siblings without adversely affecting the next generation, so that highly consistent genes can be created.

　　One thing to remember is that these rodents are not primates. Although primates are genetically very similar to humans (99% similarity), the use of primates in research has caused widespread controversy. Therefore, the next rodent is the best research object. It is also worth mentioning that the genes of rats and mice are susceptible to mutations.

　　Another factor to consider is that all content may be based on previous research work. As mentioned earlier, the number of rats and mice used in the laboratory has grown exponentially. In fact, this increase may be one of the driving factors for the increase in the use of rats and mice in the laboratory. If the scientist needs to select specific animals for the experiment, it is wise to choose the same animals as those studies in order to cross-validate with related or similar studies.