小鼠动物实验,动物造模 z-bio 2021-05-20 372

　　Normally, the temperature for mouse experiments is 20-26 degrees Celsius, but mice will only feel warm in an environment of 30 degrees Celsius. However, it is believed that mice can stay healthy in a colder environment because they need to consume more energy to maintain body temperature. In addition, researchers recently wrote in "Cancer Trends" that more and more evidence shows that even very mild cold stress can bias the results of research on cancer and inflammation.

　　Bonnie Hanland, an immunologist at the Roswell Park Cancer Research Center in the United States, said: “Most people only focus on experimental results obtained at standard laboratory temperatures.” Mouse experiments can draw different conclusions.

　　There are many reasons to keep the laboratory cold. Researchers wear long coats, gloves and masks for animal testing. A cold environment can make people more comfortable and reduce unpleasant odors. The National Committee of the United States has provided recommendations for 20 to 26 degrees Celsius and recommended materials for nesting animals. However, if the mouse needs to generate heat from time to time to maintain body temperature, then the cold will change the heart rate and metabolism, and need to eat more food for energy.

　　A few years ago, Highlander and the center's immunologist Elizabethepasky and colleagues began to study the effect of cold stress on the immune system of mice against tumors. In 2013, the research team found that laboratory mice have high resistance to cancer in their natural state (appropriate temperature). Compared with standard laboratory temperature mice, tumors grow slower and have a lower probability of metastasis. Mice that felt warm also responded well to chemotherapy.

　　Now, Highlander and Repasky are calling for people to wake up. However, Repasky emphasized: "I don't know which temperature is better. I think more research is needed to determine the best animal test temperature."