压力负荷型慢性心衰大鼠模型,动物造模 z-bio 2021-12-23 451

　　Objective: To use electrocardiogram to detect and analyze the characteristics of chronic heart failure rats with pressure overload.

　　Method: 20 male SD rats were randomly divided into sham operation group (S group) and heart failure group (HF group). In the heart failure group, abdominal aortic valve stenosis was used to establish the model, and in the sham operation group, only threading was performed without contraction. Ⅱ The reed electrocardiogram detects the limbs of the reed and carries out statistical analysis.

　　Results: 10 weeks after the operation, the ECG examination showed the following characteristics: Heart failure group (HF group): (1) Heart rate, P wave amplitude and P wave time limit increased significantly (P). u003c0.05); ②Compared with S group rats, the R wave amplitude increased significantly (P\u003c0.05). (3) The displacement of the J point of the electrocardiogram was significantly increased (P\u003c0.05), and the ST height was significantly reduced (P\u003c0.05).

　　Conclusion: The electrocardiogram characteristics of pressure-overloaded heart failure rats are very clear. As a non-invasive method, ECG detection can effectively assess pressure-overloaded heart failure in rats.