动物造模,阿尔茨海默氏病模型 z-bio 2021-10-14 1190

　　A new study shows that ultrasound scans can help remove plaques and restore memory in a mouse model of Alzheimer's disease. The mechanism is to stimulate microglia and swallow disease-causing plaques, which are a fighter for the brain's immune system. Unlike traditional drug-based methods, this non-invasive technology is still in the early stages of testing, but it is possible that one day it will be effective against this neurodegenerative disease and the accumulation of other abnormal proteins in the brain. The disease offers several possible treatments. strategy. Brain damage in Alzheimer's disease is usually caused by amyloid plaques, which are abnormal deposits of protein fragments called beta-amyloid. The treatment of Alzheimer's disease and many other brain diseases is elusive, partly because of the blood-brain barrier. The blood-brain barrier is a layer of tightly connected protective cells that block blood flow. brain. Gerhard Leinenga and JürgenG? tz used scanning ultrasound to penetrate the brains of mice to study whether beta-amyloid plaques could be removed. Scanning ultrasound is a type of transmission of sound waves into tissues to capture images of internal organs and footsteps. Elephant. Focused ultrasound can generate high-energy sound waves and can be used in combination with injected microbubbles. The microbubbles vibrate in response to ultrasonic waves, thereby temporarily opening the blood-brain barrier. The use of focused ultrasound and microbubbles to penetrate the human brain has been tested in monkeys. Leinenga and G? tz repeatedly applied this technique to the brains of mice with beta-amyloid plaques over several weeks. They found that ultrasound can almost completely remove plaque in 75% of mice without damaging the brain tissue. Compared with untreated mice, the treated mice showed improved memory and performed better in the three memory tests. These three memory tests are the "Y Maze" (Y Maze), which is a new object recognition test where activities can be actively avoided at this location. Analysis of brain tissue showed that ultrasound stimulated microglia (i.e. immune cells that phagocytic fragments) to absorb more β-amyloid plaques. The authors of the study plan to test focused ultrasound and microbubble technology in a sheep model of Alzheimer's disease.