动物造模,巨噬细胞 z-bio 2021-05-24 322

　　Specific fibrotic diseases of the whole body and human organs are one of the most serious health problems in the world, and the mortality rate accounts for most of the world's population. The cause is not clear, but its molecular pathway is complicated. Chronic inflammatory cell infiltration is the most common symptom of fibrotic lesions. Recently, it has been found that monocytes and macrophages are the core of inflammation and fibrosis. However, the exact mechanism of action involving the initiation or progression of the fibrotic process of monocytes/macrophages remains unclear. Several subgroups of monocytes and macrophages have been identified, some of which have specific phenotypes that promote inflammation, and others have fibrotic effects. The target for the monocyte/macrophage subpopulation has not been resolved, because the fibrotic disease has not yet been effectively treated. The monocyte/macrophage subpopulation plays an important regulatory role in liver fibrosis, and the treatment strategy will continue to grow. . In this regard, we provide an overview of monocytes/macrophages whose role has been established in animal models of tissue fibrosis and phenotypic cell subgroups of human or organ-specific fibrotic diseases. In addition, in response to phenotypic differences, we have identified different subpopulations of monocytes and macrophages, and designed the most advanced effective anti-fibrosis therapies.