动物模型,高血压 z-bo 2020-08-06 656

　　It refers to the hypertension caused by cutting off the decompression nerve of the animal's aorta and the nerve of the carotid sinus. The experiment generally uses dogs or rabbits, and occasionally also uses rats.

　　(1) Reproduction method The dog is fixed after anesthesia, and the carotid arteries on both sides are separated to the bifurcation of the internal and external carotid arteries. Separate, ligate and cut the carotid sinus nerve, then cut off the vagus nerves on both sides, stabilize for about 30 minutes [mean arterial pressure higher than 150mmHg (20kPa)] can cause hypertension. The operation methods of rabbits and rats are similar.

　　(2) Model characteristics The decompression reflex originating from the carotid sinus and the baroreceptors of the aortic arch plays a very important role in the regulation of blood pressure. Stimulating the efferent nerve fibers has an inhibitory effect on the vascular motor center, and its removal can lead to a continuous increase in blood pressure. This method can induce acute neurological hypertension in dogs. This type of hypertension in rabbits is not as stubborn as dogs. The general duration does not exceed 4 months. The blood pressure value can be increased by 4 to 6.7kPa.

　　(3) Comparative medicine This model is not widely used, and is mainly suitable for acute experiments. Because the hypertension caused by nerve transection is not as stable as renal ischemic hypertension, it is not suitable for chronic experiments. In the past, sinoaortic denervation (SAD) animals have been used as neurogenic hypertension models. However, it is currently believed that long-term SAD animals only have increased blood volatility and low average arterial pressure, so they should not be used as a chronic hypertension model. At present, SAD animals are often used for experimental research on decompression reflex and blood pressure fluctuation.