动物造模,阿尔茨海默病,PRNP突变体 z-bio 2021-05-25 763

　　Alzheimer's disease is one of the dementias that damage human nerves caused by β-amyloid, and there is currently no cure. The on virus protein is the receptor of β-amyloid protein, one of the important proteins in the pathogenesis of Alzheimer's disease, and plays two roles: the transmission of neurotoxicity and the protection of nerve cells. The polymorphism of the human viral protein coding gene (PNRP) affects the incubation period and clinical manifestations of Alzheimer's disease, and the discovery of PRNP mutant mice enhances and supplements the application value of animal models in the research of viral protein diseases. To some extent, this overcomes the shortcomings of existing animal models of Alzheimer's disease. This article summarizes the role of viral proteins in the pathology of Alzheimer's disease and the effect of PRNP mutation on Alzheimer's disease, and summarizes the discovery of PRNP mutant mice and its application in the study of protein precipitation-like lesions And value.