动物造模,右心衰竭动物模型 z-bio 2021-12-02 828

　　Right ventricular dysfunction (RVF) is the systolic and/or diastolic dysfunction of the right ventricle. There are many reasons for it. These reasons are insufficient or unable to normally produce the required cardiac output of the human body. Clinical syndromes occur when pressure cannot be formed. It is mainly seen in pulmonary arterial hypertension (PAH), right ventricular myocardial infarction and left ventricular insufficiency (left ventricular insufficiency, LVF). At present, the disability and mortality rate of RVF is higher than that of LVF, and the 5-year mortality rate caused by PAH is as high as 30% to 50%.

　　However, the current research on RVF lags far behind LVF. The compensation mechanism of the right ventricle in PAH and other diseases and the cellular and molecular mechanisms of right ventricular decompensation are still unknown. Therefore, it is necessary to conduct a detailed investigation of the RVF. Establishing an effective animal model of RVF plays an important role in the detailed study of the pathogenesis, pathophysiology, prevention and treatment of RVF. However, many RVF animal experiments have different modeling methods and different selection and processing conditions, so no animal model can be identified. This article summarizes and compares and evaluates the methods of establishing RVF animal models reported in the literature for future reference when conducting RVF animal experimental research.