动物造模,小鼠骨质疏松模型 z-bio 2021-05-27 440

　　Glucocorticoids are steroid hormones secreted by the fascia of the adrenal cortex, and can also be artificially synthesized by chemical methods. It has the function of regulating the synthesis and metabolism of carbohydrates, fats and proteins. Suppress immune response, anti-inflammatory and anti-toxic. , There is a shockproof effect. However, long-term use of glucocorticoids can lead to bone loss and even severe osteoporosis, which greatly increases the risk of fractures. Therefore, research on the mechanism and treatment of hormone-induced osteoporosis has become more and more important. Currently, according to different administration methods, there are three main methods for establishing hormone-induced osteoporosis models in mice: modified-release drug transplantation, oral administration and injection. Each model is uniquely suitable for each method of constructing a model, because it is only partially similar to the clinical manifestations of human osteoporosis, and cannot fully simulate the pathological changes of human osteoporosis. Existing studies have shown that the construction of hormone-induced osteoporosis models is mainly achieved by regulating endocrine, promoting bone resorption, inhibiting osteoblasts and reducing bone production. Compared with other animals, mice have advantages such as highly homologous genomes with humans, the development of inbred lines, mature gene modification technology and economic advantages, and use hormone-induced mouse osteoporosis models for bone Porosity research.