动物造模,无菌鼠结直肠癌模型 z-bio 2021-05-27 374

　　More and more evidences show that the composition of the intestinal flora is closely related to the development of colorectal cancer. Embryo-free animal models, especially sterile mouse models, are simple and easy to use, providing an important tool for studying the complex relationship between the microbiota, colorectal tumors and the body. The establishment of a sterile mouse model is mainly achieved by caesarean section, reproduction and reproduction in a sterile isolator. Based on this, it is possible to establish a special type of genetically modified or drug-induced sterile mouse model, depending on specific research goals. Currently, sterile mouse models are widely used in colorectal cancer research. Research results based on a sterile mouse model show that microorganisms or flora can activate immunity and induce inflammation, thereby promoting the development of colorectal cancer. At the same time, it has been proved that the micro-ecological imbalance, the development and disease of the large intestine have been proved. Cancer is complementary. The sterile mouse model is an important and effective research carrier for the study of colorectal cancer and related diseases caused by the imbalance of microecological ecology, so it is worthy of further promotion and application.