动物造模,肾纤维化动物模型 z-bio 2021-12-04 526

　　Renal fibrosis is a common pathological pathway required to develop from chronic kidney disease to end-stage renal disease, and its pathological changes include renal interstitial fibrosis and glomerulosclerosis. The ideal animal model of renal fibrosis is of practical importance for the study of the etiology of chronic kidney disease and the development of therapeutic drugs. Currently, animal models of renal fibrosis include drug or toxicity induction, surgical models and gene knockout. Different animal models have unique characteristics in renal function and renal histopathology, and cannot fully simulate human chronic kidney disease. This shows the complexity. Predicting the onset of chronic kidney disease is very important for understanding and preventing its pathological mechanism.