前列腺癌人源性异种移植模型 z-bio 2021-05-28 519

　　The establishment of a high-fidelity prostate cancer PDX model is the basis of prostate cancer biology and drug treatment research. However, since most prostate cancers are closely related to hormones, the success rate of primary prostate cancer transplanted into mice is low, which hinders its development and application. The fidelity prostate cancer PDX model can accurately summarize the tissue structure characteristics and biological and molecular heterogeneity of the disease, and the disease progression and drug responsiveness are very similar to clinical results. In this article, improvements to the establishment of a prostate cancer PDX model include exogenous androgen supplementation, the quality of the original tumor tissue and stromal environment, and the application of common therapeutic agents that provide reasonableness, focusing on the methods that have been completed. For clinical research of prostate cancer. These attempts are crucial for the development of new drugs for prostate cancer and their mechanism of action, thereby promoting the individual tumor treatment process for prostate cancer.