动物造模,化疗性肠黏膜炎模型 z-bio 2021-10-09 608

　　Objective: To study an animal model of intestinal mucositis induced by 5-fluorouracil-induced chemotherapy.

　　Method: 5 different doses? Use FU intraperitoneal or continuous injection for 5 days. The body weight and diarrhea of the mice were observed every day. After the last 72 or 24 hours, observe the peripheral blood and small intestine of the mice. administrative. Histopathological changes.

　　Result: 5 than the normal group? After taking FU for 5 consecutive days, the mice in each dose group experienced varying degrees of diarrhea and weight loss, and the levels of peripheral blood white blood cells and platelets were significantly reduced (P\u003c0.05 or P) u003c0 .01). Both the 400 mg/kg group and the continuous 50 mg/kg group showed obvious pathological characteristics of intestinal mucositis; the 100 mg/kg group had overdose and had a mortality rate of 100%.

　　Conclusion: 5 What about mouse intestinal mucositis? The effect of FU for a single or consecutive 5 days is dose-dependent. 400 mg/kg is the appropriate dose for a single dose, and 50 mg/kg is the appropriate dose for 5 consecutive days.