动物造模,异种移植模型 z-bio 2021-05-28 627

　　The tumor tissue xenograft (PDX) model has good similarities with the patient's primary tumor in terms of genetics, pathology and biological characteristics, and the clinical response of the drug is highly consistent. It has shown good results in the field of individualized tumor treatment. Application prospects. The use of PDX model to carry out tumor-targeted drug screening can effectively guide clinical drug use. This article reviews the evaluation strategies of PDX model for chemotherapy drug screening, summarizes modeling standards and quality control requirements, and proposes histomorphology and sequencing analysis ､Specific markers and STR detection four model traceability evaluation methods: comprehensively measure drug toxicity, tumor volume change trend and TGD mathematical model results: perform efficacy evaluation, and provide a good application strategy for PDX model to guide individualized tumor treatment ｡