动物造模,类风湿关节炎造模 z-bio 2021-05-31 485

　　Objective: To compare the success rate of collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA) in C57BL/6 mice. What is the difference in arthritis progression?

　　Method: Divide 42 mice into two groups, one group is CIA and the other is AIA? 3 mice in each group as the normal group and 18 mice as the model group? We regularly monitor the body weight of the mice after the last model construction. ? The diameter of the knee and ankle joints?

　　Result: In the context of C57BL/6, the success rate of CIA modeling is not high, and the severity of the difference is large, and the success rate of AIA modeling is high, but the maintenance time is short. Given a more comprehensive view of rheumatoid arthritis (rheumatoid arthritis, RA), is it more appropriate to create CIA models in subsequent transgenic mice?