动物造模,来源肿瘤组织异种移植模型 z-bio 2022-02-01 557

　　The tumor transplantation model established by transplanting the patient's tumor tissue into immunodeficient mice retains the biological characteristics of the primary tumor, but the matrix components of the tumor tissue are passaged in the mice. -The matrix of origin, the internal environment of mice lacking the immune system, has also changed the tumor microenvironment, gradually losing the heterogeneity of the primary tumor, limiting the application of this type of model; human hematopoietic stem cells use low-dose whole-body X-rays Stem cell (HSC) irradiation or other methods to clean the bone marrow of severely immunocompromised mice, humanized patient-derived dheterologous transplantation (Hu-PDX) on the patient’s tumor tissue has a human-like immune system , Can better maintain the heterogeneity of the primary tumor? Studies have confirmed that human HSCs can generate a variety of immune cells in mice, thereby forming a microenvironment for tumor growth. It has been found to be more similar to humans. Does it provide a good animal model for tumor heterogeneity and individual tumor research?