动物造模,体力疲劳模型 z-bio 2021-05-31 738

　　Purpose: To study sleep apnea (SI) causing physical fatigue in mice at different periods, and to provide a stable and reliable animal model for the development of products that relieve physical fatigue?

　　Method: Use roller sleep apnea to study mice in different periods (5, 10, 15 days). After sleep disturbance, run and load-bearing swimming experiments were performed on each group of animals to determine the levels of liver glycogen and serum urea nitrogen in mice. content. Decision?

　　Results: In the experiment of runners, sleep disturbance was 5 to 10 days. Compared with the control group, the 15-day group showed a decreasing trend over time, but there was no significant difference (P). 05). Compared with the blank control group for 10 days of sleep disturbance, the weight-bearing swimming fatigue time was significantly reduced (Pu003c0.05, Pu003c0.05).0.01), and the number of sinking times and total sinking time were significantly reduced (Pu003c0.0Pu003c0 .01). Compared with the control group, the 5-day, 10-day, and 15-day interference group had significantly lower liver glycogen content (Pu003c0). .05), the serum urea nitrogen content is significantly higher than that of the interference control group for 10-15 days (Pu003c0.05)?

　　Conclusion: Roller sleep disorder (roller parameter 3r/min, roller parameter 3r/min, 1 minute per revolution, 1 minute interval) will cause physical fatigue behavior in mice for 10 or 15 days?