The global incidence of autism spectrum disorder (ASD) has recently increased, but its etiology and etiology are still unclear. It is inevitable to find the etiology and etiology of the disease from animal models. Is this a trend? The research on understanding of diseases and animal models is relatively lagging. The international ASD animal models mainly include genetic models, idiopathic animal models and animal models that regulate environmental factors. They can be separated, but the research is too concentrated; BTBR model idiopathic The animal model model and the valproic acid induced model are the typical characteristics of ASD and the main application at present. A model that can better represent the clinical manifestations and certain pathogenic characteristics? ASD research still lacks completeness and structural relevance? Surface correlation? Very suitable for predicting correlation animal models?